Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment

Author:

Battula V. Lokesh1,Chen Ye1,Cabreira Maria da Graca1,Ruvolo Vivian1,Wang Zhiqiang2,Ma Wencai2,Konoplev Sergej3,Shpall Elizabeth4,Lyons Karen5,Strunk Dirk6,Bueso-Ramos Carlos3,Davis Richard Eric2,Konopleva Marina17,Andreeff Michael17

Affiliation:

1. Department of Leukemia,

2. Department of Lymphoma and Myeloma,

3. Department of Hematopathology, and

4. Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX;

5. Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA;

6. Institute of Experimental and Clinical Cell Therapy, Spinal Cord and Tissue Regeneration Center, Paracelsus Medical University, Salzburg, Austria; and

7. Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX

Abstract

Key Points Connective tissue growth factor regulates adipogenic differentiation of MSCs. Connective tissue growth factor regulates leukemia engraftment.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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