α-1-Antitrypsin (AAT)–modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics-Reference-Cited by-同舟云学术

α-1-Antitrypsin (AAT)–modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics

Published:2014-10-30 Issue:18 Volume:124 Page:2881-2891
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Marcondes A. Mario¹²,Karoopongse Ekapun¹,Lesnikova Marina¹,Margineantu Daciana¹,Welte Tobias³,Dinarello Charles A.⁴⁵,Hockenbery David¹²,Janciauskiene Sabina³,Deeg H. Joachim¹²

Affiliation:

1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. Division of Oncology, University of Washington, Seattle, WA;

3. Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany;

4. Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; and

5. Department of Medicine, University of Colorado Denver, Aurora, CO

Abstract

Key Points Donor treatment with AAT suppresses GVHD in the transplant recipient while enhancing the GVL effect. AAT effects are mediated via cell type–specific alterations of mitochondrial bioenergetics.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/18/2881/1381267/2881.pdf

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4. Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice.;Haarberg;Blood,2013

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