Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice-Reference-Cited by-同舟云学术

Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice

Published:2013-10-03 Issue:14 Volume:122 Page:2500-2511
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Haarberg Kelley M. K.¹²,Li Jun¹²,Heinrichs Jessica³,Wang Dapeng¹²,Liu Chen⁴,Bronk Crystina C.¹,Kaosaard Kane¹²,Owyang Alexander M.⁵,Holland Sacha⁵,Masuda Esteban⁵,Tso Kin⁶,Blazar Bruce R.⁷,Anasetti Claudio¹²⁸,Beg Amer A.¹⁸,Yu Xue-Zhong¹²⁸

Affiliation:

1. Department of Immunology and

2. Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;

3. Department of Pathology and Cell Biology, University of South Florida, Tampa, FL;

4. Department of Pathology, Immunology and Laboratory Medicine, University of Florida, College of Medicine, Gainesville, FL;

5. Immunology and

6. Chemistry, Rigel Pharmaceuticals, South San Francisco, CA;

7. Pediatric Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, MN; and

8. Department of Oncologic Sciences, University of South Florida, Tampa, FL

Abstract

Key Points PKCα and PKCθ cooperate in T-cell alloresponses, which contribute to GVHD. Pharmacologic inhibition of PKCα and PKCθ prevents GVHD and largely preserves GVL responses.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/14/2500/1370760/2500.pdf

Reference44 articles.

1. PKC-θ: hitting the bull’s eye.;Dustin;Nat Immunol,2011

2. PKC-θ function at the immunological synapse: prospects for therapeutic targeting.;Zanin-Zhorov;Trends Immunol,2011

3. PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice.;Valenzuela;J Clin Invest,2009

4. CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation.;Choi;Blood,2007

5. Beta2 integrins separate graft-versus-host disease and graft-versus-leukemia effects.;Liang;Blood,2008

Cited by 36 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advances in Immunosuppressive Agents Based on Signal Pathway;Frontiers in Pharmacology;2022-05-26

2. A MLR-Based Approach to Analyze Regulators of T Lymphocyte Activation In Vivo;International Journal of Molecular Sciences;2022-05-10

3. Selective Targeting of Protein Kinase C (PKC)-θ Nuclear Translocation Reduces Mesenchymal Gene Signatures and Reinvigorates Dysfunctional CD8+ T Cells in Immunotherapy-Resistant and Metastatic Cancers;Cancers;2022-03-21

4. Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome;Nature Communications;2021-12

5. The Emerging Function of PKCtheta in Cancer;Biomolecules;2021-02-05