HLA class II upregulation during viral infection leads to HLA-DP–directed graft-versus-host disease after CD4+ donor lymphocyte infusion-Reference-Cited by-同舟云学术

HLA class II upregulation during viral infection leads to HLA-DP–directed graft-versus-host disease after CD4+ donor lymphocyte infusion

Published:2013-09-12 Issue:11 Volume:122 Page:1963-1973
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Stevanović Sanja¹,van Bergen Cornelis A. M.¹,van Luxemburg-Heijs Simone A. P.¹,van der Zouwen Boris¹,Jordanova Ekaterina S.²,Kruisselbrink Alwine B.¹,van de Meent Marian¹,Harskamp Jessica C.¹,Claas Frans H. J.³,Marijt Erik W. A.¹,Zwaginga Jaap Jan³,Halkes Constantijn J. M.¹,Jedema Inge¹,Griffioen Marieke¹,Falkenburg J. H. Frederik¹

Affiliation:

1. Department of Hematology, Leiden University Medical Center, The Netherlands;

2. Centre for Gynecologic Oncology Amsterdam, Department of Obstetrics and Gynecology, The Free University, Vrije Universiteit, Amsterdam, The Netherlands; and

3. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands

Abstract

Key Points GVHD after HLA-DPB1–mismatched CD4+ DLI after TCD-alloSCT is mediated by allo-reactive HLA-DPB1–directed CD4+ T cells. Viral infections after TCD-alloSCT can induce HLA class II on nonhematopoietic tissues, making them targets for CD4+ T cells in GVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/11/1963/1331372/1963.pdf

Reference50 articles.

1. Long-term follow-up of myeloablative allogeneic stem cell transplantation using Campath “in the bag” as T-cell depletion: the Leiden experience.;Barge;Bone Marrow Transplant,2006

2. T-cell depletion of HLA-identical transplants in leukemia.;Marmont;Blood,1991

3. High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution.;Chakrabarti;Blood,2002

4. Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation.;Collins;J Clin Oncol,1997

5. Dose-escalated donor lymphocyte infusions following reduced intensity transplantation: toxicity, chimerism, and disease responses.;Peggs;Blood,2004

Cited by 68 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Immunological harmony: the dynamic influence of cellular and humoral immunity on pregnancy success;Discover Immunity;2024-08-20

2. Risk factors for graft-versus-host-disease after donor lymphocyte infusion following T-cell depleted allogeneic stem cell transplantation;Frontiers in Immunology;2024-03-13

3. Development of an explainable AI system using routine clinical parameters for rapid differentiation of inflammatory conditions;Frontiers in Immunology;2024-03-06

4. HLA-DPB1 genotype variants predict DP molecule cell surface expression and DP donor specific antibody binding capacity;Frontiers in Immunology;2024-01-11

5. Clinical impact of cytomegalovirus reactivation and immune reconstitution after allogeneic hematopoietic cell transplantation;Japanese Journal of Transplantation and Cellular Therapy;2024