LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo-Reference-Cited by-同舟云学术

LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo

Published:2013-08-08 Issue:6 Volume:122 Page:1034-1041
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lee Y. Terry¹,de Vasconcellos Jaira F.¹,Yuan Joan²,Byrnes Colleen¹,Noh Seung-Jae¹,Meier Emily R.¹,Kim Ki Soon¹,Rabel Antoinette¹,Kaushal Megha¹,Muljo Stefan A.²,Miller Jeffery L.¹

Affiliation:

1. Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, and

2. Integrative Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

Abstract

Key Points LIN28B regulates HbF expression in erythroblasts that are cultured from umbilical cord and adult human blood. LIN28B expression manifested a more fetal-like phenotype among adult human erythroblasts.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/6/1034/1375220/1034.pdf

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