Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD-Reference-Cited by-同舟云学术

Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD

Published:2013-08-01 Issue:5 Volume:122 Page:837-841
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Dertschnig Simone¹,Nusspaumer Gretel¹,Ivanek Robert¹,Hauri-Hohl Mathias M.²,Holländer Georg A.¹³,Krenger Werner¹

Affiliation:

1. Department of Biomedicine, University of Basel and Basel University Children’s Hospital, Basel, Switzerland;

2. Benaroya Research Institute, Virginia Mason Hospital, Seattle, WA; and

3. Department of Paediatrics and the Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

Abstract

Key Points Acute GVHD predisposes to autoimmune chronic GVHD, but it is currently unclear how autoimmunity is linked to antecedent alloimmunity. Loss of central tolerance induction that occurs via functional compromise of thymic epithelial cells may provide such a pathogenic link.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/5/837/1374326/837.pdf

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