Graft-versus-host disease: a disorder of tissue regeneration and repair-Reference-Cited by-同舟云学术

Graft-versus-host disease: a disorder of tissue regeneration and repair

Published:2021-11-04 Issue:18 Volume:138 Page:1657-1665
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chakraverty Ronjon¹^ORCID,Teshima Takanori²^ORCID

Affiliation:

1. Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom; and

2. Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan

Abstract

Abstract Regenerative failure at barrier surfaces and maladaptive repair leading to fibrosis are hallmarks of graft-versus-host disease (GVHD). Although immunosuppressive treatment can control inflammation, impaired tissue homeostasis leads to prolonged organ damage and impaired quality of life. In this Blood Spotlight, we review recent research that addresses the critical failures in tissue regeneration and repair that underpin treatment-resistant GVHD. We highlight current interventions designed to overcome these defects and provide our assessment of the future therapeutic landscape.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

https://ashpublications.org/blood/article-pdf/138/18/1657/1832877/bloodbld2021011867.pdf

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