Plasma biomarkers of risk for death in a multicenter phase 3 trial with uniform transplant characteristics post–allogeneic HCT

Author:

Abu Zaid Mohammad12,Wu Juan3,Wu Cindy3,Logan Brent R.4,Yu Jeffrey12,Cutler Corey5,Antin Joseph H.5,Paczesny Sophie12,Choi Sung Won6

Affiliation:

1. Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN;

2. Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN;

3. The Emmes Corporation, Rockville, MD;

4. Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI;

5. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and

6. Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI

Abstract

Key Points High ST2 and TIM3 at day 28 after allogeneic HCT were associated with nonrelapse mortality and overall survival at 2 years. Low day 28 L-Ficolin was associated with VOD/SOS and high CXCL9 correlated with chronic GVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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