Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia-Reference-Cited by-同舟云学术

Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia

Published:2017-04-27 Issue:17 Volume:129 Page:2395-2407
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tasian Sarah K.¹²³^ORCID,Kenderian Saad S.⁴⁵,Shen Feng¹²,Ruella Marco⁴⁶⁷,Shestova Olga⁴⁶⁷,Kozlowski Miroslaw⁴⁶⁷,Li Yong¹²,Schrank-Hacker April⁶⁷,Morrissette Jennifer J. D.⁶⁷,Carroll Martin⁷⁸,June Carl H.⁴⁶⁷,Grupp Stephan A.¹²³,Gill Saar⁴⁷⁸

Affiliation:

1. Division of Oncology and

2. Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA;

3. Department of Pediatrics and

4. Center for Cellular Immunotherapies, Translational Research Program, University of Pennsylvania School of Medicine, Philadelphia, PA;

5. Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN; and

6. Department of Pathology and Laboratory Medicine,

7. Abramson Cancer Center, and

8. Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

Abstract

Key Points Depletion of CD123-redirected CAR T cells with monoclonal antibodies preserves leukemia remission in human AML xenograft models. AML CAR T-cell depletion enhances feasibility of subsequent allogeneic stem cell transplantation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/17/2395/1400364/blood736041.pdf

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