Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

Author:

Placke Theresa12,Faber Katrin3,Nonami Atsushi4,Putwain Sarah L.5,Salih Helmut R.26,Heidel Florian H.7,Krämer Alwin28,Root David E.9,Barbie David A.49,Krivtsov Andrei V.10,Armstrong Scott A.10,Hahn William C.49,Huntly Brian J.5,Sykes Stephen M.11,Milsom Michael D.12,Scholl Claudia3,Fröhling Stefan12

Affiliation:

1. Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany;

2. German Consortium for Translational Cancer Research, Heidelberg, Germany;

3. Department of Internal Medicine III, Ulm University, Ulm, Germany;

4. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

5. Department of Haematology, Cambridge Institute of Medical Research, and Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom;

6. Department of Hematology and Oncology, Eberhard Karls University, Tübingen, Germany;

7. Department of Hematology and Oncology, Otto von Guericke University, Magdeburg, Germany;

8. Clinical Cooperation Unit Molecular Hematology and Oncology, German Cancer Research Center, and Department of Internal Medicine V, Ruprecht Karls University, Heidelberg, Germany;

9. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA;

10. Leukemia Center, Human Oncology and Pathogenesis Program and Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY;

11. Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA; and

12. Heidelberg Institute for Stem Cell Technology and Experimental Medicine and Division of Stem Cells and Cancer, Experimental Hematology Group, German Cancer Research Center, Heidelberg, Germany

Abstract

Key Points CDK6 is a critical effector of MLL fusions in myeloid leukemogenesis. Genetic and pharmacologic inhibition of CDK6 overcome the differentiation block associated with MLL-rearranged AML.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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