Atypical chronic myeloid leukemia is clinically distinct from unclassifiable myelodysplastic/myeloproliferative neoplasms

Author:

Wang Sa A.1,Hasserjian Robert P.2,Fox Patricia S.3,Rogers Heesun J.4,Geyer Julia T.5,Chabot-Richards Devon6ORCID,Weinzierl Elizabeth7,Hatem Joseph8,Jaso Jesse1,Kanagal-Shamanna Rashmi1,Stingo Francesco C.3,Patel Keyur P.1,Mehrotra Meenakshi1,Bueso-Ramos Carlos1,Young Ken H.1,Dinardo Courtney D.9,Verstovsek Srdan9,Tiu Ramon V.10,Bagg Adam8,Hsi Eric D.4,Arber Daniel A.7,Foucar Kathryn6,Luthra Raja1,Orazi Attilio5

Affiliation:

1. Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX;

2. Department of Pathology, Massachusetts General Hospital, Boston, MA;

3. Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston, TX;

4. Department of Clinical Pathology, Cleveland Clinic Foundation, Cleveland, OH;

5. Department of Pathology, Weill Cornell Medical College, New York, NY;

6. Department of Pathology, University of New Mexico, Albuquerque, NM;

7. Department of Pathology, Stanford University, Stanford, CA;

8. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA;

9. Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX; and

10. Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic Foundation, Cleveland, OH

Abstract

Key Points Within MDS/MPN, the WHO 2008 criteria for aCML identify a subgroup of patients with aggressive clinical features distinct from MDS/MPN-U. The MDS/MPN-U category is heterogeneous, and patient risk can be further stratified by a number of clinicopathological parameters.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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