The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits-Reference-Cited by-同舟云学术

The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits

Published:2016-10-13 Issue:15 Volume:128 Page:1969-1978
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Byrnes James R.¹,Wilson Clare²,Boutelle Anthony M.¹,Brandner Chase B.¹,Flick Matthew J.³,Philippou Helen²^ORCID,Wolberg Alisa S.¹^ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine and McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC;

2. Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine, Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, United Kingdom; and

3. Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Research Foundation, Cincinnati, OH

Abstract

Key Points Fibrinogen γ-chain residues 390 to 396 bind FXIII-A2B2 and mediate its activation in a FXIII-B subunit-dependent mechanism. Excess FXIII-B2 in plasma circulates bound to fibrinogen.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/15/1969/1395949/1969.pdf

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