Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin α-chain crosslinking

Author:

Byrnes James R.1,Duval Cédric2,Wang Yiming3,Hansen Caroline E.456,Ahn Byungwook456,Mooberry Micah J.7,Clark Martha A.8,Johnsen Jill M.910,Lord Susan T.1,Lam Wilbur A.456,Meijers Joost C. M.1112,Ni Heyu3,Ariëns Robert A. S.2,Wolberg Alisa S.1ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine and McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC;

2. Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom;

3. Canadian Blood Services, and Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, Toronto, Canada;

4. School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA;

5. Wallace C. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA;

6. Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA;

7. Department of Medicine and

8. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC;

9. Research Institute, Bloodworks Northwest, Seattle, WA;

10. Department of Medicine, University of Washington, Seattle, WA;

11. Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; and

12. Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands

Abstract

Key Points In the absence of FXIIIa activity, red blood cells are extruded from clots during clot contraction. Factor XIIIa promotes red blood cell retention in contracting clots by crosslinking fibrin α-chains.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3