Bifurcated BACH2 control coordinates mantle cell lymphoma survival and dispersal during hypoxia-Reference-Cited by-同舟云学术

Bifurcated BACH2 control coordinates mantle cell lymphoma survival and dispersal during hypoxia

Published:2017-08-10 Issue:6 Volume:130 Page:763-776
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhang Han¹,Chen Zheng¹,Miranda Roberto N.²,Medeiros L. Jeffrey²,McCarty Nami¹

Affiliation:

1. Center for Stem Cell and Regenerative Disease, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX; and

2. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Abstract

Key Points Downregulation of BACH2 increases MCL proliferation, dispersal, and drug resistance. Distinct crosstalk between BACH2 and HIF-1α under different physiological conditions modifies MCL properties.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/6/763/1404859/blood767293.pdf

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