Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation

Author:

Huang Chuanxin1,Geng Huimin2,Boss Isaac1,Wang Ling1,Melnick Ari1

Affiliation:

1. Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY; and

2. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA

Abstract

Key Points BCL6 and BACH2 cooperatively regulate GC B-cell development. The cooperative action of BCL6 and BACH2 is through both transcriptional and biochemical mechanisms.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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