Platelets and platelet-derived factor Va confer hemostatic competence in complete factor V deficiency-Reference-Cited by-同舟云学术

Platelets and platelet-derived factor Va confer hemostatic competence in complete factor V deficiency

Published:2015-06-04 Issue:23 Volume:125 Page:3647-3650
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bouchard Beth A.¹,Chapin John¹,Brummel-Ziedins Kathleen E.¹,Durda Peter²,Key Nigel S.³,Tracy Paula B.¹

Affiliation:

1. Department of Biochemistry, and

2. Department of Pathology, University of Vermont College of Medicine, Burlington, VT; and

3. Department of Medicine, Division of Hematology/Oncology, University of North Carolina, Chapel Hill, NC

Abstract

Key PointsAdministration of plasma to a factor V–deficient individual yields a stable platelet factor V/Va pool derived from megakaryocyte endocytosis. Platelets and platelet-derived factor V/Va promote and extend hemostasis well after depletion of the plasma-derived factor V pool.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/23/3647/1387954/3647.pdf

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