Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation-Reference-Cited by-同舟云学术

Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

Published:2014-04-10 Issue:15 Volume:123 Page:2389-2400
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rishi Loveena¹,Hannon Maura²,Salomè Mara¹,Hasemann Marie³⁴⁵,Frank Anne-Katrine³⁴⁵,Campos Joana¹,Timoney Jennifer²,O’Connor Caitriona¹,Cahill Mary R.²,Porse Bo³⁴⁵,Keeshan Karen¹

Affiliation:

1. Paul O’Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland;

2. University College Cork, Cork, Ireland;

3. The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences,

4. Biotech Research and Innovation Center, and

5. Danish Stem Cell Centre Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

Abstract

Key Points E2F1 regulates Trib2 expression and C/EBPα modulates E2F1-induced Trib2 activity at the granulocyte macrophage progenitor stage. Pharmacological inhibition of the cell cycle resulting in a block in E2F1 or Trib2 knockdown abrogates AML cell proliferation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/15/2389/1375459/2389.pdf

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4. Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.;Keeshan;Cancer Cell,2006

5. Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.;Wouters;Blood,2007

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