Tribbles in acute leukemia-Reference-Cited by-同舟云学术

Tribbles in acute leukemia

Published:2013-05-23 Issue:21 Volume:121 Page:4265-4270
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Liang Kai Ling¹,Rishi Loveena²,Keeshan Karen²

Affiliation:

1. University College Cork, Cork, Ireland; and

2. Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

Abstract

Abstract There is growing research interest in the mammalian Tribbles (Trib) family of serine/threonine pseudokinases and their oncogenic association with acute leukemias. This review is to understand the role of Trib genes in hematopoietic malignancies and their potential as targets for novel therapeutic strategies in acute myeloid leukemia and acute lymphoblastic leukemia. We discuss the role of Tribs as central signaling mediators in different subtypes of acute leukemia and propose that inhibition of dysregulated Trib signaling may be therapeutically beneficial.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/21/4265/1365913/4265.pdf

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4. Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.;Satoh;Nature,2013

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