Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling-Reference-Cited by-同舟云学术

Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling

Published:2014-05-22 Issue:21 Volume:123 Page:3327-3335
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Taskesen Erdogan¹,Havermans Marije¹,van Lom Kirsten¹,Sanders Mathijs A.¹,van Norden Yvette²,Bindels Eric¹,Hoogenboezem Remco¹,Reinders Marcel J. T.³⁴,Figueroa Maria E.⁵,Valk Peter J. M.¹,Löwenberg Bob¹,Melnick Ari⁶,Delwel Ruud¹²

Affiliation:

1. Department of Hematology, and

2. Clinical Trial Center, Erasmus University Medical Center, Rotterdam, The Netherlands;

3. Delft Bioinformatics Laboratory, Delft University of Technology, Delft, The Netherlands;

4. Netherlands Bioinformatics Centre, Nijmegen, The Netherlands;

5. University of Michigan, Ann Arbor, MI; and

6. Department of Medicine, Hematology Oncology Division, Cornell, NY

Abstract

Key Points SF-mutant myeloid malignancies transcend the boundaries between AML and MDS. Integrated analysis of gene expression and DNA-methylation profiles in leukemia uncovers novel subtypes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/21/3327/1377706/3327.pdf

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