International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data-Reference-Cited by-同舟云学术

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

Published:2022-09-15 Issue:11 Volume:140 Page:1200-1228
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Arber Daniel A.¹^ORCID,Orazi Attilio²,Hasserjian Robert P.³^ORCID,Borowitz Michael J.⁴,Calvo Katherine R.⁵,Kvasnicka Hans-Michael⁶^ORCID,Wang Sa A.⁷,Bagg Adam⁸,Barbui Tiziano⁹^ORCID,Branford Susan¹⁰^ORCID,Bueso-Ramos Carlos E.⁷,Cortes Jorge E.¹¹^ORCID,Dal Cin Paola¹²,DiNardo Courtney D.⁷^ORCID,Dombret Hervé¹³,Duncavage Eric J.¹⁴,Ebert Benjamin L.¹⁵^ORCID,Estey Elihu H.¹⁶,Facchetti Fabio¹⁷,Foucar Kathryn¹⁸,Gangat Naseema¹⁹^ORCID,Gianelli Umberto²⁰^ORCID,Godley Lucy A.¹,Gökbuget Nicola²¹,Gotlib Jason²²,Hellström-Lindberg Eva²³,Hobbs Gabriela S.³^ORCID,Hoffman Ronald²⁴,Jabbour Elias J.⁷,Kiladjian Jean-Jacques¹³,Larson Richard A.¹^ORCID,Le Beau Michelle M.¹,Loh Mignon L.-C.²⁵,Löwenberg Bob²⁶^ORCID,Macintyre Elizabeth²⁷^ORCID,Malcovati Luca²⁸^ORCID,Mullighan Charles G.²⁹^ORCID,Niemeyer Charlotte³⁰^ORCID,Odenike Olatoyosi M.¹,Ogawa Seishi³¹^ORCID,Orfao Alberto³²,Papaemmanuil Elli³³,Passamonti Francesco²⁸^ORCID,Porkka Kimmo³⁴^ORCID,Pui Ching-Hon²⁹,Radich Jerald P.³⁵,Reiter Andreas³⁶,Rozman Maria³⁷,Rudelius Martina³⁸,Savona Michael R.³⁹^ORCID,Schiffer Charles A.⁴⁰,Schmitt-Graeff Annette⁴¹^ORCID,Shimamura Akiko¹⁵⁴²^ORCID,Sierra Jorge⁴³,Stock Wendy A.¹,Stone Richard M.¹⁵,Tallman Martin S.⁴⁴,Thiele Jürgen⁴⁵,Tien Hwei-Fang⁴⁶,Tzankov Alexandar⁴⁷,Vannucchi Alessandro M.⁴⁸^ORCID,Vyas Paresh⁴⁹^ORCID,Wei Andrew H.⁵⁰^ORCID,Weinberg Olga K.⁵¹,Wierzbowska Agnieszka⁵²^ORCID,Cazzola Mario²⁸^ORCID,Döhner Hartmut⁵³^ORCID,Tefferi Ayalew¹⁹

Affiliation:

1. 1University of Chicago, Chicago, IL;

2. 2Texas Tech University Health Sciences Center El Paso, El Paso, TX;

3. 3Massuchusetts General Hospital, Boston, MA;

4. 4Johns Hopkins University, Baltimore, MD;

5. 5National Institutes of Health Clinical Center, Bethesda, MD;

6. 6Helios Universitätsklinikum Wuppertal, Wuppertal, Germany;

7. 7University of Texas MD Anderson Cancer Center, Houston, TX;

8. 8University of Pennsylvania, Philadelphia, PA;

9. 9Clinical Research Foundation, Papa Giovanni XXIII Hospital, Bergamo, Italy;

10. 10Centre for Cancer Biology, Adelaide, SA, Australia;

11. 11Georgia Cancer Center, Augusta, GA;

12. 12Brigham and Women’s Hospital, Boston, MA;

13. 13Université Paris Cité, Hôpital Saint-Louis, Assistance Publique - Hôpitaux de Paris, Paris, France;

14. 14Washington University in St Louis, St. Louis, MO;

15. 15Dana-Farber Cancer Institute, Boston, MA;

16. 16University of Washington, Seattle, WA;

17. 17University of Brescia School of Medicine, Brescia, Italy;

18. 18University of New Mexico, Albuquerque, NM;

19. 19Mayo Clinic, Rochester, MN;

20. 20Università degli Studi di Milano, Milan, Italy;

21. 21Goethe University, Frankfurt, Germany;

22. 22Stanford University School of Medicine, Stanford, CA;

23. 23Karolinska Institutet, Solna, Sweden;

24. 24Mount Sinai Medical Center, New York, NY;

25. 25Seattle Children’s Hospital, Seattle, WA;

26. 26Erasmus Medical Center, Rotterdam, Netherlands;

27. 27Université Paris Cité, Paris, France;

28. 28University of Pavia, Pavia, Italy;

29. 29St. Jude Children’s Research Hospital, Memphis, TN

30. 30University of Freiburg Medical Center, Freiburg um Breisgau, Germany;

31. 31Kyoto University, Kyoto, Japan;

32. 32University of Salamanca, Salamanca, Spain;

33. 33Memorial Sloan-Kettering Cancer Center, New York, NY;

34. 34Helsinki University Central Hospital Comprehensive Cancer Center, Helsinki, Finland;

35. 35Fred Hutchinson Cancer Research Center, Seattle, WA;

36. 36University Hospital Mannheim, Mannheim, Germany;

37. 37University of Barcelona, Barcelona, Spain;

38. 38Ludwig Maximilians University Munich, Munich, Germany;

39. 39Vanderbilt University School of Medicine, Nashville, TN;

40. 40Karmanos Cancer Institute, Detroit, MI;

41. 41Albert-Ludwigs-University Freiburg, Freiburg im Breisgau, Germany

42. 42Boston Children’s Cancer and Blood Disorders Center, Boston, MA;

43. 43Hospital Santa Creu i Sant Pau, Barcelona, Spain;

44. 44Lurie Children’s Hospital, Chicago, IL;

45. 45University of Cologne, Köln, Germany;

46. 46National Taiwan University Hospital, Taipei City, Taiwan;

47. 47Medical University Basel, Basel, Switzerland;

48. 48University of Florence and AOU Careggi, Florence, Italy;

49. 49University of Oxford, Oxford, United Kingdom;

50. 50Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia;

51. 51University of Texas Southwestern, Dallas, TX;

52. 52Medical University of Lodz, Lodz, Poland; and

53. 53University Hospital Ulm, Ulm, Germany

Abstract

Abstract The classification of myeloid neoplasms and acute leukemias was last updated in 2016 within a collaboration between the World Health Organization (WHO), the Society for Hematopathology, and the European Association for Haematopathology. This collaboration was primarily based on input from a clinical advisory committees (CACs) composed of pathologists, hematologists, oncologists, geneticists, and bioinformaticians from around the world. The recent advances in our understanding of the biology of hematologic malignancies, the experience with the use of the 2016 WHO classification in clinical practice, and the results of clinical trials have indicated the need for further revising and updating the classification. As a continuation of this CAC-based process, the authors, a group with expertise in the clinical, pathologic, and genetic aspects of these disorders, developed the International Consensus Classification (ICC) of myeloid neoplasms and acute leukemias. Using a multiparameter approach, the main objective of the consensus process was the definition of real disease entities, including the introduction of new entities and refined criteria for existing diagnostic categories, based on accumulated data. The ICC is aimed at facilitating diagnosis and prognostication of these neoplasms, improving treatment of affected patients, and allowing the design of innovative clinical trials.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

https://ashpublications.org/blood/article-pdf/140/11/1200/1921032/bloodbld2022015850c.pdf

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