mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation

Author:

Yang Jun1,Zhou Xuan12,Fan Xiaorong1,Xiao Min1,Yang Dinghua3,Liang Bo3,Dai Meng4,Shan Lanlan4,Lu Jingbo5,Lin Zhiqi5,Liu Rong6,Liu Jun7,Wang Liping89,Zhong Mei8,Jiang Yu9,Bai Xiaochun1ORCID

Affiliation:

1. State Key Laboratory of Organ Failure Research, Department of Cell Biology, School of Basic Medical Sciences,

2. Department of Hematology, Zhujiang Hospital,

3. Department of Hepatobiliary Surgery, Nanfang Hospital,

4. Department of Health Management Center, Nanfang Hospital,

5. Department of Vascular Surgery, Nanfang Hospital, and

6. Health Management Center, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China;

7. Department of Urology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China;

8. Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China; and

9. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA

Abstract

Key Points Activation of mTORC1 in MKs and platelets contributes to aging-related venous thrombosis. ROS production with aging activates mTORC1 to elevate MPV and platelet activation and promote venous thrombosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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