Phenotypic, transcriptomic, and genomic features of clonal plasma cells in light-chain amyloidosis

Author:

Paiva Bruno1,Martinez-Lopez Joaquin2,Corchete Luis A.3,Sanchez-Vega Beatriz2,Rapado Inmaculada2,Puig Noemi3,Barrio Santiago2,Sanchez Maria-Luz4,Alignani Diego1,Lasa Marta1,García de Coca Alfonso5,Pardal Emilia6,Oriol Alberto7,Garcia Maria-Esther Gonzalez8,Escalante Fernando9,González-López Tomás J.10,Palomera Luis11,Alonso José12,Prosper Felipe1,Orfao Alberto4,Vidriales Maria-Belen3,Mateos María-Victoria3,Lahuerta Juan-Jose2,Gutierrez Norma C.3,San Miguel Jesús F.1

Affiliation:

1. Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain;

2. Hospital 12 de Octubre, Madrid, Spain;

3. Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigación del Cancer (IBMCC CSIC-USAL), Salamanca, Spain;

4. Servicio General de Citometría and Department of Medicine, IBSAL, and IBMCC CSIC-USAL, Salamanca, Universidad de Salamanca, Salamanca, Spain;

5. Hospital Clínico Universitario de Valladolid, Valladolid, Spain;

6. Hospital Virgen del Puerto, Plasencia, Spain;

7. Hospital German Trias i Pujol, Badalona, Spain;

8. Hospital de Cabueñes, Gijón, Spain;

9. Complejo Hospitalario de León, León, Spain;

10. Hospital Universitario de Burgos, Burgos, Spain;

11. Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain; and

12. Hospital Rio Carrión, Palencia, Spain

Abstract

Key Points Clonal PCs in AL have similar phenotypic and CNA profiles as those in MM, but their transcriptome is similar to that of normal PCs. First-ever WES in AL amyloidosis reveals potential lack of a unifying mutation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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