Gain of chromosome 1q21 is an independent adverse prognostic factor in light chain amyloidosis patients treated with melphalan/dexamethasone-Reference-Cited by-同舟云学术

Gain of chromosome 1q21 is an independent adverse prognostic factor in light chain amyloidosis patients treated with melphalan/dexamethasone

Published:2014-01-23 Issue:1 Volume:21 Page:9-17
ISSN:1350-6129
Container-title:Amyloid
language:en
Short-container-title:Amyloid

Author:

Bochtler Tilmann,Hegenbart Ute,Kunz Christina,Benner Axel,Seckinger Anja,Dietrich Sascha,Granzow Martin,Neben Kai,Goldschmidt Hartmut,Ho Anthony D.,Hose Dirk,Jauch Anna,Schönland Stefan O.

Publisher

Informa UK Limited

Subject

Internal Medicine

Link

http://www.tandfonline.com/doi/pdf/10.3109/13506129.2013.854766

Reference43 articles.

1. Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis

2. Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis

3. Evaluation of the cytogenetic aberration pattern in amyloid light chain amyloidosis as compared with monoclonal gammopathy of undetermined significance reveals common pathways of karyotypic instability

4. Translocation t(11;14) and survival of patients with light chain (AL) amyloidosis

5. Hyperdiploidy is less frequent in AL amyloidosis compared with monoclonal gammopathy of undetermined significance and inversely associated with translocation t(11;14)

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