Mouse plasmacytoid dendritic cells derive exclusively from estrogen-resistant myeloid progenitors-Reference-Cited by-同舟云学术

Mouse plasmacytoid dendritic cells derive exclusively from estrogen-resistant myeloid progenitors

Published:2006-08-01 Issue:3 Volume:108 Page:878-885
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Harman Benjamin C.¹,Miller Juli P.¹,Nikbakht Neda¹,Gerstein Rachel¹,Allman David¹

Affiliation:

1. From the Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA; and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA.

Abstract

Abstract Current models predict that mouse plasmacytoid dendritic cells (PDCs) derive from lymphoid progenitors. However, we show PDCs arise exclusively from common myeloid progenitors (CMPs) characterized by low-level expression of several lymphoid-associated genes, including a RAG2/GFP reporter transgene. This conclusion is supported by both adoptive transfer experiments and an estrogen treatment strategy that led to marked depletion of very early lymphoid progenitors without affecting RAG2/GFP+ CMPs or the developmental kinetics, RAG-mediated recombinase activity, and cytokine production of PDCs. These data suggest that PDCs arise exclusively from early myeloid progenitors and that promiscuous low-level expression of lymphoid-associated genes is a general feature of PDC progenitors among CMPs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/108/3/878/1282790/zh801506000878.pdf

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