Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia-Reference-Cited by-同舟云学术

Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia

Published:2016-07-28 Issue:4 Volume:128 Page:574-583
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Thijssen Rachel¹²,ter Burg Johanna¹²,Garrick Brett³,van Bochove Gregor G. W.¹²,Brown Jennifer R.⁴,Fernandes Stacey M.⁴,Rodríguez María Solé⁵,Michot Jean-Marie⁶,Hallek Michael⁷,Eichhorst Barbara⁷,Reinhardt Hans Christian⁷,Bendell Johanna⁸,Derks Ingrid A. M.¹,van Kampen Roel J. W.⁹,Hege Kristen³,Kersten Marie José²¹⁰,Trowe Torsten³,Filvaroff Ellen H.³,Eldering Eric¹¹⁰,Kater Arnon P.²¹⁰

Affiliation:

1. Department of Experimental Immunology and

2. Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;

3. Celgene, San Francisco, CA;

4. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

5. Department of Hematology, Hospital Universitario Virgen del Rocío, Seville, Spain;

6. Department of Hematology, Institut Gustave Roussy, Villejuif, France;

7. Department of Hematology, University Hospital, Cologne, Germany;

8. Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN;

9. Orbis Medisch Centrum, Sittard, The Netherlands; and

10. Lymphoma and Myeloma Center Amsterdam, The Netherlands

Abstract

Key Points TORK/DNA-PK inhibition induces cytotoxicity and blocks signaling pathways important for CLL survival, proliferation, and drug resistance. Preliminary clinical effects of TORK/DNA-PK inhibition show 7 of 8 CLL patients with decreased lymphadenopathy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/4/574/1398422/574.pdf

Reference64 articles.

1. Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22.;Ghia;Eur J Immunol,2002

2. The lymphatic tissue microenvironments in chronic lymphocytic leukemia: in vitro models and the significance of CD40-CD154 interactions.;Burger;Blood,2009

3. Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance.;Kurtova;Blood,2009

4. Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro.;Panayiotidis;Br J Haematol,1996

5. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1.;Burger;Blood,2000

Cited by 66 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development and therapeutic potential of DNA-dependent protein kinase inhibitors;Bioorganic Chemistry;2024-09

2. Concomitant inhibition of the thioredoxin system and nonhomologous DNA repair potently sensitizes Philadelphia‐positive lymphoid leukemia to tyrosine kinase inhibitors;HemaSphere;2024-03

3. Phase I study of peposertib and avelumab with or without palliative radiotherapy in patients with advanced solid tumors;ESMO Open;2024-02

4. Targeting the DNA damage response in hematological malignancies;Frontiers in Oncology;2024-01-29

5. Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK);Journal of Enzyme Inhibition and Medicinal Chemistry;2023-07-24