Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE−/− mice and activate platelets via TLR2-Reference-Cited by-同舟云学术

Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE−/− mice and activate platelets via TLR2

Published:2016-05-26 Issue:21 Volume:127 Page:2618-2629
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Biswas Sudipta¹,Xin Liang²,Panigrahi Soumya¹,Zimman Alejandro¹,Wang Hua²,Yakubenko Valentin P.¹,Byzova Tatiana V.¹,Salomon Robert G.²,Podrez Eugene A.¹

Affiliation:

1. Department of Molecular Cardiology, The Cleveland Clinic, Cleveland, OH; and

2. Department of Chemistry, Case Western Reserve University, Cleveland, OH

Abstract

Key Points CAP-PEs, a novel type of oxidatively modified phospholipids, are present in vivo. CAP-PEs can activate platelets via TLRs by inducing a cross-talk between innate immunity and integrin activation signaling pathways.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/21/2618/1393732/2618.pdf

Reference44 articles.

1. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo.;Watson;J Biol Chem,1997

2. Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease.;Tsimikas;N Engl J Med,2005

3. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions.;Podrez;J Biol Chem,2002

4. Oxidized phosphatidylcholine in alveolar macrophages in idiopathic interstitial pneumonias.;Yoshimi;Lung,2005

5. Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNE.;Annangudi;Chem Res Toxicol,2008

Cited by 41 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Morvan’s syndrome with hypercoagulable condition in a patient positive for anti-CASPR2 antibodies: A case report;Medicine;2024-07-19

2. Platelets in Alcohol-Associated Liver Disease: Interaction With Neutrophils;Cellular and Molecular Gastroenterology and Hepatology;2024

3. Mechanism of Tumor-Platelet Communications in Cancer;Circulation Research;2023-05-26

4. Activation of Most Toll-Like Receptors in Whole Human Blood Attenuates Platelet Deposition on Collagen under Flow;Journal of Immunology Research;2023-01-17

5. Mechanism Research of Platelet Core Marker Prediction and Molecular Recognition in Cardiovascular Events;Combinatorial Chemistry & High Throughput Screening;2023-01