MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance-Reference-Cited by-同舟云学术

MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance

Published:2015-11-19 Issue:21 Volume:126 Page:2355-2361
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kwok Brian¹,Hall Jeff M.¹,Witte John S.²,Xu Yin¹,Reddy Prashanti¹,Lin Keming¹,Flamholz Rachel¹,Dabbas Bashar¹,Yung Aine¹,Al-Hafidh Jenan¹,Balmert Emily¹,Vaupel Christine¹,El Hader Carlos¹,McGinniss Matthew J.¹,Nahas Shareef A.¹,Kines Julie¹,Bejar Rafael³

Affiliation:

1. Genoptix Medical Laboratory, Carlsbad, CA;

2. Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA; and

3. Division of Hematology-Oncology, Moores Cancer Center at the University of California at San Diego, La Jolla, CA

Abstract

Key Points Over 30% of patients with unexplained cytopenias who do not meet diagnostic criteria for MDS carry MDS-associated somatic mutations. Clonal cytopenias of undetermined significance are more common than MDS and show comparable variant allele frequencies and blood counts.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/21/2355/1389872/2355.pdf

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