Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia-Reference-Cited by-同舟云学术

Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia

Published:2016-03-31 Issue:13 Volume:127 Page:1687-1700
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhang Qifang¹²,Hossain Dewan Md Sakib¹,Duttagupta Priyanka¹,Moreira Dayson¹,Zhao Xingli¹,Won Haejung¹,Buettner Ralf³,Nechaev Sergey¹,Majka Marcin⁴,Zhang Bin³⁵,Cai Qi³,Swiderski Piotr⁶,Kuo Ya-Huei³⁵,Forman Stephen³,Marcucci Guido³⁵,Kortylewski Marcin¹

Affiliation:

1. Department of Immuno-Oncology, Beckman Research Institute at City of Hope, Duarte, CA;

2. Key Laboratory of Medical Molecular Biology, Guizhou Medical University, Guiyang, People’s Republic of China;

3. Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute at City of Hope, Duarte, CA;

4. Department of Transplantation, Jagiellonian University Medical College, Cracow, Poland;

5. Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA; and

6. DNA/RNA Synthesis Core Facility, Beckman Research Institute at City of Hope, Duarte, CA

Abstract

Key Points STAT3 decoy conjugated to TLR9 ligand targets survival and immune checkpoint signaling in all acute myeloid leukemia cell compartments. Serum-resistant CpG-STAT3dODN conjugates induce direct killing and/or immune-mediated eradication of AML, including stem/progenitor cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/13/1687/1392299/1687.pdf

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