Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans-Reference-Cited by-同舟云学术

Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans

Published:2015-01-29 Issue:5 Volume:125 Page:815-819
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Choi Sung Won¹,Gatza Erin¹,Hou Guoqing¹,Sun Yaping²,Whitfield Joel³,Song Yeohan¹,Oravecz-Wilson Katherine²,Tawara Isao⁴,Dinarello Charles A.⁵,Reddy Pavan²

Affiliation:

1. Department of Pediatrics,

2. Department of Internal Medicine, Division of Hematology-Oncology, Blood and Marrow Transplantation Program, and

3. Immunology Core, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI;

4. Department of Hematology-Oncology, Mie University Hospital, Tsu, Mie, Japan; and

5. Department of Medicine, Division of Infectious Diseases, University of Colorado, Aurora, CO

Abstract

Key Points HDAC inhibition reduced proinflammatory cytokines and increased regulatory T-cell number and function after allo-HCT. HDAC inhibition enhanced signal transducer and activator of transcription 3 acetylation and induced indoleamine-2,3-dioxygenase after allo-HCT.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/5/815/1388067/815.pdf

Reference28 articles.

1. Current and emerging strategies for the prevention of graft-versus-host disease.;Choi;Nat Rev Clin Oncol,2014

2. Advances in graft-versus-host disease biology and therapy.;Blazar;Nat Rev Immunol,2012

3. Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect.;Reddy;Proc Natl Acad Sci USA,2004

4. Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice.;Reddy;J Clin Invest,2008

5. Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3.;Sun;J Immunol,2009

Cited by 92 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The roles of epigenetic regulation in graft-versus-host disease;Biomedicine & Pharmacotherapy;2024-06

2. Induction of indoleamine 2,3-dioxygenase 1 expression in neurons of the central nervous system through inhibition of histone deacetylases blocks the progression of experimental autoimmune encephalomyelitis;International Immunopharmacology;2024-06

3. Targeting post-translational modifications of Foxp3: a new paradigm for regulatory T cell-specific therapy;Frontiers in Immunology;2023-10-23

4. Elucidating the direct effects of the novel HDAC inhibitor bocodepsin (OKI-179) on T cells to rationally design regimens for combining with immunotherapy;Frontiers in Immunology;2023-09-06

5. The impact of epigenetic modifications on allogeneic hematopoietic stem cell transplantation;Frontiers in Immunology;2023-05-31