Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia-Reference-Cited by-同舟云学术

Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia

Published:2014-04-03 Issue:14 Volume:123 Page:2139-2147
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rossi Davide¹,Khiabanian Hossein²,Spina Valeria¹,Ciardullo Carmela¹,Bruscaggin Alessio¹,Famà Rosella¹,Rasi Silvia¹,Monti Sara¹,Deambrogi Clara¹,De Paoli Lorenzo¹,Wang Jiguang²,Gattei Valter³,Guarini Anna⁴,Foà Robin⁴,Rabadan Raul²,Gaidano Gianluca¹

Affiliation:

1. Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy;

2. Department of Systems Biology and Department of Biomedical Informatics, Center for Computational Biology and Bioinformatics, Institute for Cancer Genetics, Columbia University, New York, NY;

3. Clinical and Experimental Onco-Hematology, Centro di Riferimento Oncologico, Aviano, Italy; and

4. Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy

Abstract

Key Points Small TP53 mutated subclones have the same unfavorable prognostic impact as clonal TP53 defects in chronic lymphocytic leukemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/14/2139/1375210/2139.pdf

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5. The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness.;Rossi;Clin Cancer Res,2009

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