Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia

Author:

Rossi Davide1,Rasi Silvia1,Spina Valeria1,Bruscaggin Alessio1,Monti Sara1,Ciardullo Carmela1,Deambrogi Clara1,Khiabanian Hossein2,Serra Roberto3,Bertoni Francesco4,Forconi Francesco56,Laurenti Luca7,Marasca Roberto8,Dal-Bo Michele9,Rossi Francesca Maria9,Bulian Pietro9,Nomdedeu Josep10,Del Poeta Giovanni11,Gattei Valter9,Pasqualucci Laura121314,Rabadan Raul2,Foà Robin15,Dalla-Favera Riccardo121316,Gaidano Gianluca1

Affiliation:

1. Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy;

2. Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics, Columbia University, New York, NY;

3. Laboratory of Medical Informatics, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy;

4. Lymphoma and Genomics Research Program, IOR-Institute of Oncology Research and Lymphoma Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland;

5. Cancer Sciences Unit, CRUK Clinical Centre, University of Southampton, Southampton, United Kingdom;

6. Division of Hematology, University of Siena, Siena, Italy;

7. Institute of Hematology, Catholic University of the Sacred Heart, Rome, Italy;

8. Division of Hematology, Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, Italy;

9. Clinical and Experimental Onco-Hematology, Centro di Riferimento Oncologico, Aviano, Italy;

10. Department of Hematology and Laboratory, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;

11. Department of Hematology, Tor Vergata University, Rome, Italy;

12. Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY;

13. Department of Pathology & Cell Biology, Columbia University, New York, NY;

14. Institute of Hematology, Department of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy;

15. Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy; and

16. Department of Genetics & Development, Columbia University, New York, NY

Abstract

Key Points The integration of mutations and cytogenetic lesions improves the accuracy of survival prediction in chronic lymphocytic leukemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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