Deletion of Fanca or Fancd2 dysregulates Treg in mice-Reference-Cited by-同舟云学术

Deletion of Fanca or Fancd2 dysregulates Treg in mice

Published:2014-03-20 Issue:12 Volume:123 Page:1938-1947
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Du Wei¹,Erden Ozlem¹,Wilson Andrew¹,Sipple Jared M.¹,Schick Jonathan¹,Mehta Parinda²³,Myers Kasiani C.²³,Steinbrecher Kris A.³⁴,Davies Stella M.²³,Pang Qishen¹³

Affiliation:

1. Division of Experimental Hematology and Cancer Biology,

2. Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH;

3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH; and

4. Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Abstract

Key Points Deletion of Fanca or Fancd2 dysregulates the activity and function of regulatory T cells. The loss of FA proteins alters the expression of Foxp3 target genes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/12/1938/1375944/1938.pdf

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