Chromosomal Aberrations Associated with Clonal Evolution and Leukemic Transformation in Fanconi Anemia: Clinical and Biological Implications-Reference-Cited by-同舟云学术

Chromosomal Aberrations Associated with Clonal Evolution and Leukemic Transformation in Fanconi Anemia: Clinical and Biological Implications

Published:2012 Issue: Volume:2012 Page:1-6
ISSN:2090-1267
Container-title:Anemia
language:en
Short-container-title:Anemia

Author:

Meyer Stefan¹²³,Neitzel Heidemarie⁴,Tönnies Holger⁵

Affiliation:

1. c/o Young Oncology Unit, Department of Paediatric and Adolescent Oncology, Christie Hospital, Wilmslow Road, Manchester M20 6XB, UK

2. Stem Cell & Leukaemia Proteomics Laboratory, School of Cancer and Enabling Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

3. Department of Paediatric Oncology, Royal Manchester Children's Hospital Oxford Road, Manchester M13 9WL, UK

4. Institute for Medical and Human Genetics, Charité Universitätsmedizin Berlin, Germany, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany

5. Gendiagnostik Kommission, Robert Koch Institut, DGZ-Ring 1, 13086 Berlin, Germany

Abstract

Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities, bone marrow failure, and extreme risk of leukemic transformation. Bone marrow surveillance is an important part of the clinical management of FA and often reveals cytogenetic aberrations. Here, we review bone marrow findings in FA and discuss the clinical and biological implications of chromosomal aberrations associated with leukemic transformation.

Publisher

Hindawi Limited

Subject

Cell Biology,Hematology

Link

http://downloads.hindawi.com/journals/anemia/2012/349837.pdf

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