Ibrutinib inhibits BCR and NF-κB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL-Reference-Cited by-同舟云学术

Ibrutinib inhibits BCR and NF-κB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL

Published:2014-05-22 Issue:21 Volume:123 Page:3286-3295
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Herman Sarah E. M.¹,Mustafa Rashida Z.¹,Gyamfi Jennifer A.¹,Pittaluga Stefania²,Chang Stella³,Chang Betty³,Farooqui Mohammed¹,Wiestner Adrian¹

Affiliation:

1. Hematology Branch, National Heart, Lung and Blood Institute and

2. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD; and

3. Pharmacyclics Inc., Sunnyvale, CA

Abstract

Key Points Ibrutinib inhibits both BCR and NF-κB signaling in lymph node and bone marrow resident CLL cells. Rapid and sustained reduction of cellular activation and tumor proliferation was achieved in all anatomic compartments.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/21/3286/1377498/3286.pdf

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