Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia

Author:

Rossi Davide1,Spina Valeria1,Bomben Riccardo2,Rasi Silvia1,Dal-Bo Michele2,Bruscaggin Alessio1,Rossi Francesca Maria2,Monti Sara1,Degan Massimo2,Ciardullo Carmela1,Serra Roberto3,Zucchetto Antonella2,Nomdedeu Josep4,Bulian Pietro2,Grossi Alberto5,Zaja Francesco6,Pozzato Gabriele7,Laurenti Luca8,Efremov Dimitar G.9,Di-Raimondo Francesco10,Marasca Roberto11,Forconi Francesco1213,Del Poeta Giovanni14,Gaidano Gianluca1,Gattei Valter2

Affiliation:

1. Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy;

2. Clinical and Experimental Onco-Hematology, Centro di Riferimento Oncologico, Aviano, Italy;

3. Laboratory of Medical Informatics, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy;

4. Department of Hematology and Laboratory, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;

5. Hematology, Istituto Fiorentino di Cura e Assistenza Firenze, Italy;

6. Clinica Ematologica, Centro Trapianti e Terapie Cellulari Carlo Melzi, Dipartimento di Scienze Mediche Sperimentali e Cliniche Azienda Ospedaliero-Universitaria S. M. Misericordia, Udine, Italy;

7. Department of Internal Medicine and Haematology, Maggiore Hospital, Trieste, Italy;

8. Institute of Hematology, Catholic University of the Sacred Heart, Rome, Italy;

9. Molecular Hematology, International Centre for Genetic Engineering & Biotechnology, Campus A. Buzzati-Traverso, Rome, Italy;

10. Section of Hematology, Oncology, and Clinical Pathology, Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy;

11. Division of Hematology, Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, Italy;

12. Cancer Sciences Unit, Cancer Research UK Clinical Centre, University of Southampton, Southampton, United Kingdom;

13. Division of Hematology, University of Siena, Siena, Italy; and

14. Department of Hematology, Tor Vergata University, Rome, Italy

Abstract

Key Points BCR subsets 2 and 8 show specific genetic profiles influencing CLL course.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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