Nonpermissive HLA-DPB1 mismatch increases mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation

Author:

Pidala Joseph1,Lee Stephanie J.2,Ahn Kwang Woo3,Spellman Stephen4,Wang Hai-Lin3,Aljurf Mahmoud5,Askar Medhat6,Dehn Jason7,Fernandez Viña Marcelo8,Gratwohl Alois9,Gupta Vikas10,Hanna Rabi6,Horowitz Mary M.3,Hurley Carolyn K.11,Inamoto Yoshihiro2,Kassim Adetola A.12,Nishihori Taiga1,Mueller Carlheinz13,Oudshoorn Machteld14,Petersdorf Effie W.2,Prasad Vinod15,Robinson James1617,Saber Wael3,Schultz Kirk R.18,Shaw Bronwen161719,Storek Jan20,Wood William A.21,Woolfrey Ann E.2,Anasetti Claudio1

Affiliation:

1. H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;

2. Fred Hutchinson Cancer Research Center, Seattle, WA;

3. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;

4. Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN;

5. King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia;

6. Cleveland Clinic Foundation, Cleveland, OH;

7. National Marrow Donor Program, Minneapolis, MN;

8. Stanford Hospital and Clinics, Stanford, CA;

9. University Hospital Basel, Basel, Switzerland;

10. Princess Margaret Hospital, Toronto, ON, Canada;

11. Georgetown University Hospital, Washington, DC;

12. Vanderbilt University Medical Center, Nashville, TN;

13. ZKRD-Zentrales Knochenmarkspender-Register Deutschland, Ulm, Germany;

14. Europdonor Foundation, Leiden University Medical Centre, Leiden, The Netherlands;

15. Duke University Medical Center, Durham, NC;

16. Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom;

17. UCL Cancer Institute, University College, London, United Kingdom;

18. British Columbia’s Children’s Hospital, University of British Columbia, Vancouver, BC, Canada;

19. Royal Marsden, Sutton, Surrey, United Kingdom;

20. University of Calgary, Calgary, AB, Canada; and

21. University of North Carolina Hospitals, Chapel Hill, NC

Abstract

Key Points High-resolution matching for HLA-A, -B, -C, and -DRB1 is required for optimal survival in myeloablative-unrelated donor transplantation. HLA-DPB1 nonpermissive mismatches should be avoided in otherwise matched transplants to minimize overall mortality.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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