Circular RNA enrichment in platelets is a signature of transcriptome degradation-Reference-Cited by-同舟云学术

Circular RNA enrichment in platelets is a signature of transcriptome degradation

Published:2016-03-03 Issue:9 Volume:127 Page:e1-e11
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Alhasan Abd A.¹,Izuogu Osagie G.¹^ORCID,Al-Balool Haya H.²,Steyn Jannetta S.¹³^ORCID,Evans Amanda⁴,Colzani Maria⁴,Ghevaert Cedric⁴,Mountford Joanne C.⁵⁶^ORCID,Marenah Lamin⁶,Elliott David J.¹,Santibanez-Koref Mauro¹,Jackson Michael S.¹

Affiliation:

1. Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom;

2. Kuwait Medical Genetics Centre, Al-Sabah Medical Area, Kuwait City, Kuwait;

3. Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom;

4. National Health Service Blood and Transplant, Department of Haematology, University of Cambridge, Cambridge, United Kingdom;

5. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; and

6. Tissue and Cellular Therapies, Research Development & Innovation, Scottish National Blood Transfusion Service, Glasgow, United Kingdom

Abstract

Key Points Circular RNAs are hugely enriched in platelets compared with nucleated cell types. Lack of enrichment in megakaryocte progenitors implicates degradation of platelet linear RNAs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/9/e1/1396122/e1.pdf

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4. Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in healthy human volunteers.;Harker;Blood,2000

5. Protein synthesis by platelets: historical and new perspectives.;Weyrich;J Thromb Haemost,2009

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