Clonal interference of signaling mutations worsens prognosis in core-binding factor acute myeloid leukemia

Author:

Itzykson Raphael12ORCID,Duployez Nicolas34,Fasan Annette5,Decool Gauthier34,Marceau-Renaut Alice34,Meggendorfer Manja5,Jourdan Eric6,Petit Arnaud7,Lapillonne Hélène8,Micol Jean-Baptiste9,Cornillet-Lefebvre Pascale10,Ifrah Norbert11,Leverger Guy7,Dombret Hervé112,Boissel Nicolas112,Haferlach Torsten5,Preudhomme Claude34

Affiliation:

1. Department of Hematology, Hôpital Saint-Louis, Assistance Publique–Hopitaux de Paris (AP-HP), Paris Diderot University, Paris, France;

2. INSERM/Centre National de la Recherche Scientifique, Unité Mixte de Recherche 944/7212, Paris Cancer Research Institute, Paris, France;

3. INSERM Lille, University of Lille, Lille, France;

4. Laboratory of Hematology, Centre Hospitalier Universitaire Lille, Lille, France;

5. Munich Leukemia Laboratory, Munich, Germany;

6. Centre Hospitalier Universitaire de Nîmes, Nimes, France;

7. Pediatric Hematology and Oncology Department and

8. Laboratory of Hematology, Trousseau Hospital, AP-HP, Paris, France;

9. Department of Hematology, Gustave Roussy Institute, Villejuif, France;

10. Laboratory of Hematology, Centre Hospitalier Universitaire, Reims, France;

11. Clinical Hematology Department, Hotel-Dieu, Angers, France; and

12. EA3518, Paris Diderot University, Paris, France

Abstract

Key Points Presence of ≥2 independent subclones in the receptor tyrosine kinase/RAS pathway, defining clonal interference, is found in 28% of CBF AMLs. Clonal interference predicts shorter event-free survival independently of clinical variables and presence of specific signaling mutations.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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