cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner-Reference-Cited by-同舟云学术

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

Published:2014-04-17 Issue:16 Volume:123 Page:2562-2572
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wong W. Wei-Lynn¹²³,Vince James E.¹²,Lalaoui Najoua¹²,Lawlor Kate E.¹²,Chau Diep¹,Bankovacki Aleksandra¹,Anderton Holly¹,Metcalf Donald¹²,O’Reilly Lorraine¹²,Jost Philipp J.¹,Murphy James M.¹²,Alexander Warren S.¹²,Strasser Andreas¹²,Vaux David L.¹²,Silke John¹²³

Affiliation:

1. The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia;

2. Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia; and

3. Department of Biochemistry, La Trobe University, Bundoora, VIC, Australia

Abstract

Key Points cIAPs and XIAP negatively regulate cytokine production, including TNF to disrupt myeloid lineage differentiation. IAPs prevent RIPK1 and RIPK3 activity to limit cytokine production prior to cell death.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/16/2562/1376323/2562.pdf

Reference50 articles.

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4. Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation.;Mahoney;Proc Natl Acad Sci USA,2008

5. TNF-alpha induces two distinct caspase-8 activation pathways.;Wang;Cell,2008

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