Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity-Reference-Cited by-同舟云学术

Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity

Published:2014-10-02 Issue:14 Volume:124 Page:2223-2234
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Low Ivan Cherh Chiet¹²,Loh Thomas³,Huang Yiqing³,Virshup David M.²⁴,Pervaiz Shazib¹²⁴⁵

Affiliation:

1. Department of Physiology, National University of Singapore (NUS),

2. NUS Graduate School of Integrative Sciences and Engineering,

3. Department of Otolaryngology, National University Healthcare System, Singapore;

4. Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore; and

5. Singapore-Massachusetts Institute of Technology Alliance, Singapore

Abstract

Key Points O2− modifies B56δ at Y289 to block the PP2A holoenzyme assembly. This results in S70 Bcl-2 phosphorylation and promotes tumor chemoresistance. Primary lymphomas with low SOD1 have high B56δ tyrosine nitration and S70pBcl-2.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/14/2223/1379910/2223.pdf

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