Hyperphosphorylation of BCL-2 family proteins underlies functional resistance to venetoclax in lymphoid malignancies-Reference-Cited by-同舟云学术

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Hyperphosphorylation of BCL-2 family proteins underlies functional resistance to venetoclax in lymphoid malignancies

Published:2023-11-15 Issue:22 Volume:133 Page:
ISSN:1558-8238
Container-title:Journal of Clinical Investigation
language:en
Short-container-title:

Author:

Chong Stephen Jun Fei,Zhu Fen,Dashevsky Olga,Mizuno Rin,Lai Jolin X.H.,Hackett Liam^ORCID,Ryan Christine E.^ORCID,Collins Mary C.^ORCID,Iorgulescu J. Bryan^ORCID,Guièze Romain,Penailillo Johany^ORCID,Carrasco Ruben,Hwang Yeonjoo C.^ORCID,Muñoz Denise P.^ORCID,Bouhaddou Mehdi,Lim Yaw Chyn,Wu Catherine J.,Allan John N.,Furman Richard R.^ORCID,Goh Boon Cher,Pervaiz Shazib,Coppé Jean-Philippe^ORCID,Mitsiades Constantine S.^ORCID,Davids Matthew S.^ORCID

Funder

Simeon J. Fortin Charitable Foundation

Leukemia and Lymphoma Society

National Institutes of Health

Dana-Farber Cancer Institute Lymphoma Pilot Grant

Dana-Farber Cancer Institute Medical Oncology Grant Program

Novartis Drug Discovery and Translational Research Program

Pan-Mass Challenge Team FLAMES funding

Conquer Cancer Foundation/Sontag Foundation

Publisher

American Society for Clinical Investigation

Subject

General Medicine

Link

https://www.jci.org/articles/view/170169/files/pdf

Reference58 articles.

1. Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

2. Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia

3. Phase I First-in-Human Study of Venetoclax in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

4. Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

5. Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax

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1. Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation;Cell Death & Disease;2024-07-03

2. Recent advances in canonical versus non-canonical Ca2+-signaling-related anti-apoptotic Bcl-2 functions and prospects for cancer treatment;Biochimica et Biophysica Acta (BBA) - Molecular Cell Research;2024-06

3. Monitoring Response and Resistance to Treatment in Chronic Lymphocytic Leukemia;Cancers;2024-05-28

4. Apoptosis, a Metabolic “Head-to-Head” between Tumor and T Cells: Implications for Immunotherapy;Cells;2024-05-27

5. Therapeutic targeting of apoptosis in chronic lymphocytic leukemia;Seminars in Hematology;2024-04

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