Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders

Author:

Noris Patrizia1,Biino Ginevra2,Pecci Alessandro1,Civaschi Elisa1,Savoia Anna34,Seri Marco5,Melazzini Federica1,Loffredo Giuseppe6,Russo Giovanna7,Bozzi Valeria1,Notarangelo Lucia Dora8,Gresele Paolo9,Heller Paula G.10,Pujol-Moix Nuria11,Kunishima Shinji12,Cattaneo Marco13,Bussel James14,De Candia Erica15,Cagioni Claudia1,Ramenghi Ugo16,Barozzi Serena1,Fabris Fabrizio17,Balduini Carlo L.1

Affiliation:

1. Department of Internal Medicine, University of Pavia-Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia, Italy;

2. Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy;

3. Department of Medical Sciences, University of Trieste, Trieste, Italy;

4. Institute for Maternal and Child Health–Istituto Di Ricovero e Cura a Carattere Scientifico Burlo Garofolo, Trieste, Italy;

5. Genetica Medica, Dipartimento di Scienze Mediche Chirurgiche, Policlinico Sant’Orsola-Malpighi, University of Bologna, Bologna, Italy;

6. Department of Oncology, Azienda “Santobono-Pausilipon,” Pausilipon Hospital, Naples, Italy;

7. Division of Pediatric Hematology/Oncology, University of Catania, Catania, Italy;

8. Oncology-Haematology and Bone Marrow Transplantation Unit, Ospedale dei Bambini, Spedali Civili, Brescia, Italy;

9. Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy;

10. Department of Hematology Research, Instituto de Investigaciones Médicas Alfredo Lanari, National Scientific and Technical Research Council, University of Buenos Aires, Buenos Aires, Argentina;

11. Universitat Autònoma de Barcelona, Institut de Recerca Biomèdica Sant Pau, Barcelona, Spain;

12. Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan;

13. Medicina III Ospedale San Paolo, Dipartimento di Scienza della Salute, Università degli Studi di Milano, Milan, Italy;

14. Weill Medical College of Cornell University, New York, NY;

15. Servizio Malattie Emorragiche e Trombotiche, Istituto di Medicina Interna e Geriatria, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy;

16. Hematology Unit, Pediatric Department, University of Torino, Torino, Italy; and

17. Department of Medicine; University of Padova Medical School, Padova, Italy

Abstract

Key Points Measurement of platelet diameters in 376 patients resulted in a new classification of inherited thrombocytopenias based on platelet size. Measurement of platelet diameters is a useful tool for differential diagnosis of inherited thrombocytopenias.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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