HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies-Reference-Cited by-同舟云学术

HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies

Published:2014-08-21 Issue:8 Volume:124 Page:1266-1276
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Fernandez Christian A.¹,Smith Colton¹,Yang Wenjian¹,Daté Mihir²,Bashford Donald²,Larsen Eric³,Bowman W. Paul⁴,Liu Chengcheng¹,Ramsey Laura B.¹,Chang Tamara¹,Turner Victoria⁵,Loh Mignon L.⁶,Raetz Elizabeth A.⁷,Winick Naomi J.⁸,Hunger Stephen P.⁹,Carroll William L.⁷,Onengut-Gumuscu Suna¹⁰,Chen Wei-Min¹⁰,Concannon Patrick¹¹,Rich Stephen S.¹⁰,Scheet Paul¹²,Jeha Sima¹³,Pui Ching-Hon¹³,Evans William E.¹,Devidas Meenakshi¹⁴,Relling Mary V.¹

Affiliation:

1. Department of Pharmaceutical Sciences, and

2. Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN;

3. Maine Children’s Cancer Program, Scarborough, ME;

4. Department of Hematology and Oncology, Cook Children's Medical Center, Fort Worth, TX;

5. Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN;

6. Department of Pediatrics, University of California School of Medicine, San Francisco, CA;

7. Department of Pediatrics, New York University Medical Center, NY;

8. University of Texas Southwestern Medical Center, Dallas, TX;

9. Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation and Center for Cancer and Blood Disorders, University of Colorado Denver School of Medicine, Children’s Hospital Colorado, Aurora, CO;

10. Center for Public Health Genomics, University of Virginia, Charlottesville, VA;

11. Genetics Institute, University of Florida, Gainesville, FL;

12. Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, Houston, TX;

13. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN; and

14. Department of Biostatistics, College of Medicine, University of Florida, Gainesville, FL

Abstract

Key PointsHLA-DRB1*07:01 is associated with asparaginase hypersensitivity and anti-asparaginase antibodies. HLA-DRB1 alleles that confer high-affinity binding to asparaginase epitopes lead to a higher frequency of hypersensitivity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/8/1266/1382640/1266.pdf

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