Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis-Reference-Cited by-同舟云学术

Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis

Published:2013-12-12 Issue:25 Volume:122 Page:4107-4110
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

McGrath Rachel T.¹,van den Biggelaar Maartje²,Byrne Barry³,O’Sullivan Jamie M.¹,Rawley Orla¹,O’Kennedy Richard³,Voorberg Jan²,Preston Roger J. S.⁴,O’Donnell James S.¹⁵

Affiliation:

1. Haemostasis Research Group, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James’s Hospital, Trinity College Dublin, Ireland;

2. Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands;

3. Biomedical Diagnostics Institute and Applied Biochemistry Group, Dublin City University, Ireland;

4. National Children’s Research Centre, Our Lady’s Children’s Hospital, Crumlin, Dublin, Ireland; and

5. National Centre for Hereditary Coagulation Disorders, St James’s Hospital, Dublin, Ireland.

Abstract

Key Points Platelet-VWF exists as a distinct natural glycoform. Platelet-VWF is resistant to ADAMTS13 proteolysis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/25/4107/1371586/4107.pdf

Reference25 articles.

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4. Platelet von Willebrand factor—structure, function and biological importance.;McGrath;Br J Haematol,2010

5. Platelet factor VIII-related antigen: studies in vivo after transfusion in patients with von Willebrand disease.;Sultan;Blood,1978

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