Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8+ T cells and dendritic cells-Reference-Cited by-同舟云学术

Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8+ T cells and dendritic cells

Published:2013-06-27 Issue:26 Volume:121 Page:5184-5191
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Terrell Catherine E.¹,Jordan Michael B.¹²

Affiliation:

1. Division of Cellular and Molecular Immunology, and

2. Division of Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH

Abstract

Key PointsDefects in perforin and related genes lead to abnormal T-cell activation and are associated with HLH. The physiological mechanism by which perforin protects from HLH involves CD8+ T-cell elimination of rare antigen-presenting dendritic cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/26/5184/1367378/5184.pdf

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