HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice

Author:

Nixon Christopher C.12,Vatakis Dimitrios N.23,Reichelderfer Scott N.45,Dixit Dhaval12,Kim Sohn G.23,Uittenbogaart Christel H.126,Zack Jerome A.1234

Affiliation:

1. Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA;

2. University of California Los Angeles Center For AIDS Research, Los Angeles, CA;

3. Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA;

4. Edythe and Eli Broad Center for Stem Cell Research, University of California Los Angeles, Los Angeles, CA;

5. Department of Biology, California State University, Northridge, CA; and

6. Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA

Abstract

Key PointsSome CD34+CD38+ intermediate hematopoietic progenitor cells express HIV-1 entry receptors and are susceptible to direct infection by HIV. Blood progenitors from HIV-exposed, humanized BLT mice show impaired hematopoietic potential and give rise to progeny that harbor provirus.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference39 articles.

1. Viruses and bone marrow failure.;Rosenfeld;Blood Rev,1991

2. Bone marrow findings in HIV infection: a pathological study.;Marche;Prog AIDS Pathol,1990

3. Suppression of in vitro haematopoiesis following human immunodeficiency virus infection.;Donahue;Nature,1987

4. Peripheral blood and bone marrow abnormalities in patients with HIV related disease.;Treacy;Br J Haematol,1987

5. HIV-related thrombocytopenia.;Scaradavou;Blood Rev,2002

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