Consequences of HIV infection in the bone marrow niche

Author:

Herd Candice Lee,Mellet Juanita,Mashingaidze Tsungai,Durandt Chrisna,Pepper Michael Sean

Abstract

Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients. The bone marrow niche is a complex, multicellular environment which functions primarily in the maintenance of haematopoietic stem/progenitor cells (HSPCs). These adult stem cells are responsible for replacing blood and immune cells over the course of a lifetime. Cells of the bone marrow niche support HSPCs and help to orchestrate the quiescence, self-renewal and differentiation of HSPCs through chemical and molecular signals and cell-cell interactions. This narrative review discusses the HIV-associated dysregulation of the bone marrow niche, as well as the susceptibility of HSPCs to infection by HIV.

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

Reference259 articles.

1. The relationship between the spleen colony-forming cell and the haemopoietic stem cell;Schofield;Blood Cells,1978

2. The evolving view of the hematopoietic stem cell niche;Beerman;Exp Hematol,2017

3. Where hematopoietic stem cells live: the bone marrow niche;Szade;Antioxid Redox Signal,2018

4. Complexity of bone marrow hematopoietic stem cell niche;Asada;Int J Hematol,2017

5. The bone marrow niche for haematopoietic stem cells;Morrison;Nature.,2014

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3