EZH2 mutations are frequent and represent an early event in follicular lymphoma

Author:

Bödör Csaba12,Grossmann Vera34,Popov Nikolay1,Okosun Jessica1,O’Riain Ciarán1,Tan King5,Marzec Jacek6,Araf Shamzah1,Wang Jun6,Lee Abigail M.1,Clear Andrew1,Montoto Silvia1,Matthews Janet1,Iqbal Sameena1,Rajnai Hajnalka2,Rosenwald Andreas7,Ott German78,Campo Elias9,Rimsza Lisa M.10,Smeland Erlend B.1112,Chan Wing C.13,Braziel Rita M.14,Staudt Louis M.15,Wright George15,Lister T. Andrew1,Elemento Olivier16,Hills Robert17,Gribben John G.1,Chelala Claude6,Matolcsy András2,Kohlmann Alexander3,Haferlach Torsten3,Gascoyne Randy D.5,Fitzgibbon Jude1

Affiliation:

1. Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, United Kingdom;

2. Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary;

3. MLL Munich Leukemia Laboratory GmbH, Munich, Germany;

4. Center for Thrombosis and Hemostasis, University Medical Center Mainz, Johannes Gutenberg University, Mainz, Germany;

5. Department of Pathology, British Columbia Cancer Centre, Vancouver, BC, Canada;

6. Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom;

7. Institute of Pathology, University of Würzburg, Würzburg, Germany;

8. Department of Clinical Pathology, and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;

9. Department of Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain;

10. Department of Pathology, University of Arizona Cancer Centre, Tucson, AZ;

11. Department of Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway;

12. Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway;

13. Department of Pathology, University of Nebraska Medical Centre, Omaha, NE;

14. Department of Pathology, Oregon Health and Science University, Portland, OR;

15. Metabolism Branch, National Cancer Institute, Bethesda, MD;

16. HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, and Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY; and

17. Department of Haematology, Cardiff University School of Medicine, Cardiff, United Kingdom

Abstract

Key Points EZH2 mutations occur in more than 25% of follicular lymphoma patients. Mutations predominantly represent an early/clonal event in the pathogenesis of the disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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