Junctional adhesion molecule-A suppresses platelet integrin αIIbβ3 signaling by recruiting Csk to the integrin-c

Junctional adhesion molecule-A suppresses platelet integrin αIIbβ3 signaling by recruiting Csk to the integrin-c–Src complex

Published:2014-02-27 Issue:9 Volume:123 Page:1393-1402
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Naik Meghna U.¹²,Caplan Jeffrey L.²³,Naik Ulhas P.¹²³⁴

Affiliation:

1. Delaware Cardiovascular Research Center, and

2. Department of Biological Sciences, University of Delaware, Newark, DE;

3. Delaware Biotechnology Institute, Newark, DE; and

4. Department of Chemistry and Biochemistry, University of Delaware, Newark, DE

Abstract

Key Points Phosphorylated JAM-A associates with resting integrin αIIbβ3. JAM-A suppresses outside-in signaling by recruiting Csk to the integrin-c–Src complex.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/9/1393/1378709/1393.pdf

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4. Endogenous inhibitory mechanisms and the regulation of platelet function.;Jones;Methods Mol Biol,2012

5. Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2.;Inoue;J Cell Biol,2003

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