Immune reconstitution and survival of 100 SCID patients post–hematopoietic cell transplant: a PIDTC natural history study

Author:

Heimall Jennifer1,Logan Brent R.2,Cowan Morton J.3,Notarangelo Luigi D.4,Griffith Linda M.5,Puck Jennifer M.3,Kohn Donald B.6,Pulsipher Michael A.7,Parikh Suhag8,Martinez Caridad9,Kapoor Neena7,O’Reilly Richard10,Boyer Michael11,Pai Sung-Yun12,Goldman Frederick13,Burroughs Lauri14,Chandra Sharat15,Kletzel Morris16,Thakar Monica17,Connelly James18,Cuvelier Geoff19,Davila Saldana Blachy J.20,Shereck Evan21,Knutsen Alan22,Sullivan Kathleen E.1,DeSantes Kenneth23,Gillio Alfred24,Haddad Elie25,Petrovic Aleksandra26,Quigg Troy27,Smith Angela R.28,Stenger Elizabeth29,Yin Ziyan2,Shearer William T.9,Fleisher Thomas30,Buckley Rebecca H.8,Dvorak Christopher C.3ORCID

Affiliation:

1. Division of Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, PA;

2. Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI;

3. Division of Pediatric Allergy, Immunology and Bone Marrow Transplant, University of California, San Francisco, San Francisco, CA;

4. Laboratory of Host Defense, Division of Intramural Research, and

5. Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD;

6. Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA;

7. Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA;

8. Department of Pediatrics, Duke University, Durham, NC;

9. Texas Children's Hospital, Baylor College of Medicine, Houston, TX;

10. Memorial Sloan Kettering Cancer Center, New York, NY;

11. University of Utah Health, Salt Lake City, UT;

12. Boston Children's Hospital, Boston, MA;

13. Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL;

14. Fred Hutchinson Cancer Research Center, Seattle, WA;

15. Cincinnati Children's Hospital, Cincinnati, OH;

16. Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Northwestern University, Evanston, IL;

17. Division of Pediatric Hematology/Oncology/Transplant, Medical College of Wisconsin, Milwaukee, WI;

18. Department of Pediatrics, Vanderbilt University, Nashville, TN;

19. CancerCare Manitoba, Winnipeg, MB, Canada;

20. Division of Blood and Marrow Transplantation, Children's National Medical Center, Washington, DC;

21. Division of Pediatric Hematology/Oncology, Department of Pediatrics, Oregon Health and Science University, Portland, OR;

22. Cardinal Glennon Children's Hospital, St. Louis, MO;

23. University of Wisconsin–Madison, Madison, WI;

24. Hackensack University Medical Center, Hackensack, NJ;

25. CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, Canada;

26. Seattle Children's Hospital, Seattle, WA;

27. Methodist Children's Hospital of South Texas, San Antonio, TX;

28. Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN;

29. Children's Healthcare of Atlanta, Atlanta, GA; and

30. Clinical Center, National Institutes of Health, Bethesda, MD

Abstract

Key Points Active infection pretransplant adversely impacts survival (81% in patients with active infection vs 95% in infection-free patients; P = .009). Preparative chemotherapy improved 1-year post-HCT median CD4 counts (P = .02) and freedom from IV immunoglobulin (P < .001).

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Cited by 185 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3